Studies and Scientific References

The active medicinal ingredients in ARTHRO-FORCE, hydrolyzed collagen and MSM, are supported by the following studies and scientific references:

MSM Study – Relief of Osteoarthrtis Pain

Patients with osteoarthritis received a dose of 500 mg of MSM 3 times daily over a 12-week period. Compared to placebo, MSM significantly reduced pain and swelling. MSM produced an analgesic and anti-inflammatory effect in patients with osteoarthritis (1).

MSM Study – Effective Relief of Osteoarthritis Pain in the Knee

A randomized double-blind study (2) including 50 subjects with osteoarthritis of the knee demonstrated that a dose of 3 g MSM twice daily over a 12-week period significantly reduced joint pain and improved amplitude of movements.

MSM Study – Safety

Rats were dosed with MSM 5 to 7 times the recommended maximum in humans for a period of 90 days and no adverse effects or mortality occurred. No pathological lesions or changes in organ weights were noted and renal function was normal. It is concluded that MSM is very well tolerated (3).

MSM Study – Absorption and Security

Volunteers consumed between 1 g and 3 g of MSM a day. Magnetic resonance assessed the presence of MSM in the patients’ brains. MSM was present in both gray matter and white matter in equal amounts. In patients who did not consume MSM, no trace was found. No adverse clinical or neurochemical effects were observed. The presence of MSM in significant concentration demonstrates that it is well assimilated and crosses the cerebral blood barrier (4).

Collagen Hydrolyzate Study – Relief of Osteoarthritis Pain of the Knee

In a double-blind study (5) in several centers, 250 patients with primary osteoarthritis of the knee consumed 10 g of collagen hydrolyzate over a 6-month period. Significant improvement in knee joint symptoms and condition has been reported, particularly in those with marked deterioration of the joint who consume less protein in their usual diet.

Collagen Hydrolyzate Study – Relief of Osteoarthritis Pain in the Hip and Knee

According to an analysis of studies conducted with collagen hydrolyzate, the results of three trials (541 subjects) show that the daily intake of 10 g of collagen hydrolyzate helps to relieve pain caused by osteoarthritis of the knee and the hip (6).

Collagen Hydrolyzate Study – Safety and Security

The American Federation of Experimental Biology first assessed the safety of gelatin in 1975 (7) and in 2001 the FDA (Food & Drug Administration) reconfirmed GRAS (Generally Recognized As Safe) status. Generally Recognized as Safe, gelatin products (8). Collagen hydrolyzate, like gelatin, comes from animal collagen and is classified in this category.

The German Federal Institute for Medicines and Medical Devices and the World Health Office (WHO) have also accepted this assessment and do not restrict its application.

Collagen Hydrolyzate Study – Assimilation

For more than a decade, evidence that oral administration of collagen hydrolyzate influences the amino acid concentration in athletes’ blood is demonstrated. A marked increase in the three amino acids contained in collagen hydrolyzate was observed; glycine, proline and hydroxyproline. The concentration of alanine, asparagine, glutamic acid and tryptophan has also increased.

This demonstrates that taking collagen hydrolyzate from bovine and liquid sources is in fact well digested in the intestinal tract, and that the amino acids are assimilated in their specific form. In this study (9), 81% of the group that consumed 10 g of collagen hydrolyzate a day reported a marked improvement in their joint symptoms.

Another study (10) has also shown that the daily consumption of 10 g of collagen hydrolyzate leads to a continuous increase of proline and hydroxyproline, two amino acids found in the cartilage of the joints and found in greater quantities in collagen hydrolyzate from bovine source versus other types of collagen and proteins.

Collagen Hydrolyzate Study – Collagen Renewal in Cartilage

In a double-blind study (11), taking collagen hydrolyzate doubled the amount of nutrients present in the cartilage. This shows that the collagen hydrolyzate reaches the joint tissues. This study also showed the direct influence of collagen hydrolyzate on the production of new collagen in the joints. This could have a major impact on Osteoarthritis Disease which is characterized by the deterioration of cartilage.

Collagen Hydrolyzate Study – Symptoms Related to Fibromyalgia

A US study (12) has shown that bovine collagen hydrolyzate can help decrease the symptoms of fibromyalgia. This study showed that, after 3 months of use, patients with chronic fibromyalgia experienced:

  • Decrease in total pain by 25%
  • Improved uninterrupted and deeper sleep by 25%
  • Decrease in morning stiffness by 32%
  • Improvement of chronic headaches by 34%
  • Improved feelings of numbness by 11%
  • Improvement of irritable bowel syndrome by 36%
  • Improved memory and cognitive state by 35%


1. Usha PR, Naidu MUR. 2004. Randomized, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clinical Drug Investigation 24(6):353-363.

2. Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. 2006. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 14:286-294.

3. Horvath K, Noker PE, Somfai-Relle S, Glávits R, Financsek I, Schauss AG. 2002. Toxicity of methylsulfonylmethane in rats. Food and Chemical Toxicology 40:1459-1462.

4. Lin A, Nguy CH, Shic F, Ross BD. 2001. Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy. Toxicology Letters 123:169-177.

5. P. Benito-Ruiz & al, A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition. 2009, Vol. 60, No. s2, Pg 99-113.

6. Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. 2000 Oct. 30 (2): 87-89.

7. Evaluation of the health aspects of gelatine as a food ingredient. Federation of American Societies for Experimental Biology. U.S. Department of Commerce, National Technical Information Service. PB-254 527; 1975.

8. Collagen Hydrolysate and its Biological Value Jurgen Seifert, M.D. Collagen Hydrolysate and its Relationship to Joint Health. A scientific Compendium – Tolerability – 3: 50; 2004.

9. Beurk F. & al; Ernahrungs-Umschau 40; Heft 2; 1993.

10. Sellmeyer D.E. et al; American Journal of Clinical Nutrition 73: 118-122; 2001.

11. Oesser S. et Seifert J. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen.

12. Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. 2006. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 14:286-294.

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